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ABSTRACT.
This study compared the clinical
effectiveness of a dietary desiccated thyroid product
(Hypo Support Formula or HSF), to
that of a synthetic T3 product (Cynomel).
Methods:
A single-subject two-phase
repeated-measures study design was
used. Comparisons were made between
two study phases: the Cynomel phase
followed by the HSF phase. Clinical
evaluations included four basal
measures: metabolic rate (BMR),
heart rate (BHR), axillary
temperature (BAT), and blood
pressure (BBP). Other measures were
body composition, mean hypothyroid
symptoms intensity, Zung’s
depression scale, and pain
distribution. Study subjects were a
female stable on 87.5 mcg of Cynomel
for two years, and a male stable on
150 mcg of Cytomel or Cynomel for 24
years. In the Cynomel phase, the
female remained on Cynomel through
10 evaluations on different days;
the male subject remained on Cynomel
through 12 evaluations. After the
transition from Cynomel to HSF, she
then had 10 more evaluations; the
male subject had 12 more
evaluations.
Results: The female’s
temperature was the same in both
phases. In the HSF phase, her heart
rate was significantly lower and her
basal metabolic rate significantly
higher. A noteworthy improvement for
her in the HSF phase was virtual
elimination of lifelong, severe
hyperhidrosis. This has persisted
now for 3.5 months. The male
subject’s BMR and BAT were not
different in the two phases.
However, during the HSF phase, he
had a significantly lower heart
rate, diastolic blood pressure, pain
distribution, pain intensity, and
mean intensity of hypothyroid
symptoms.
Conclusions: Both HSF and
Cynomel were effective, but HSF
provided additional improvements.
Keywords.
Basal metabolic rate ● Basal
temperature ● Cynomel ● Cytomel ●
Desiccated thyroid ● Hypo Support
Formula ● RLC Labs ●
Triiodothyronine
Lowe, J.C.: Comparison of Cynomel
and Hypo Support Formula:
Their
physiological effects.
Thyroid Science, 4(3):CLS1-11,
2009.
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